Estimating gene regulatory networks with pandaR.
Daniel Schlauch1,2, Joseph N Paulson1,2, Albert Young1,2
1Department of Computational Biology and Biostatistics, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, MA, USA.
Bioinformatics (Oxford, England)
|March 24, 2017
Summary
This study introduces PandaR, a Bioconductor R package for data analysis. It is readily available for researchers to download and utilize in their work.
Area of Science:
- Bioinformatics
- Computational Biology
- Genomics
Background:
- The abstract provides contact information and availability details for the PandaR package.
- Specific scientific background is not detailed in the provided abstract snippet.
Purpose of the Study:
- To announce the availability of the PandaR R package.
- To provide access information for researchers interested in utilizing PandaR.
Main Methods:
- PandaR is implemented as a Bioconductor R Package.
- The package is accessible through the Bioconductor website.
Main Results:
- The PandaR package is now available to the research community.
- Researchers can access the package at bioconductor.org/packages/pandaR.
Conclusions:
- The PandaR package offers a new tool for biological data analysis.
- Easy accessibility is ensured through the Bioconductor platform.
Related Concept Videos
02:33Combinatorial Gene Control
9.8K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.8K
02:02Cis-regulatory Sequences
12.0K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
12.0K
01:23Regulation of Expression at Multiple Steps
1.5K
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.5K