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Amitriptyline-related peripheral neuropathy. Case report.

A Zampollo¹, G Sozzi, F Basso

¹Servizio di Neurofisiologia, Ospedale di Lecco, CO.

Italian Journal of Neurological Sciences

|February 1, 1988

Summary

This summary is machine-generated.

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Amitriptyline, commonly used for nerve pain, can rarely cause peripheral neuropathy (nerve damage). This case study shows that stopping the drug can lead to recovery of nerve function.

Area of Science:

Neuroscience
Pharmacology

Background:

Amitriptyline is widely prescribed for neuropathic pain.
It is generally not considered toxic to the peripheral nervous system (PNS).
Sporadic reports link amitriptyline to peripheral neuropathy after overdose or prolonged use.

Observation:

A 54-year-old man developed lower limb paresthesias after 2 years of uninterrupted amitriptyline use (150 mg/day).
Clinical examination revealed diminished ankle jerks and distal hypoesthesia.
Electromyography (EMG) indicated a sensorimotor neuropathy consistent with axonal disease.

Findings:

The patient's symptoms and EMG findings gradually normalized after discontinuing amitriptyline.
Laboratory data were within normal limits, ruling out other causes.

Related Experiment Videos

This case highlights a potential, albeit infrequent, risk of PNS neurotoxicity from amitriptyline.

Implications:

Clinicians should consider amitriptyline-induced peripheral neuropathy in patients with unexplained neurological symptoms.
Further research is warranted to understand the mechanisms and incidence of this adverse effect.
This finding challenges the perception of amitriptyline as entirely safe for the PNS.