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Updated: Mar 5, 2026

Knee Arthrocentesis in Adults
Published on: February 25, 2022
Effect of Tranexamic Acid on Transfusion Rates Following Total Joint Arthroplasty: A Cost and Comparative
Perry J Evangelista1, Michael W Aversano1, Emmanuel Koli2
1Department of Orthopaedic Surgery, Hospital for Joint Diseases, NYU Langone Medical Centre, New York University Hospital for Joint Diseases, 301 E 17th Street, 14th Floor, New York, NY 10003, New York.
Abstract:
Tranexamic acid (TXA) is used to reduce blood loss in orthopedic total joint arthroplasty (TJA). This study evaluates the effectiveness of TXA in reducing transfusions and hospital cost in TJA. Participants undergoing elective TJA were stratified into 2 cohorts: those not receiving and those receiving intravenous TXA. TXA decreased total hip arthroplasty (THA) transfusions from 22.7% to 11.9%, and total knee arthroplasty (TKA) from 19.4% to 7.0%. The average direct hospital cost reduction for THA and TKA was $3083 and $2582, respectively. Implementation of a TJA TXA protocol significantly reduced transfusions in a safe and cost-effective manner.
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