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Double-Edged Sword: Musculoskeletal Infection Provoked Acute Phase Response in Children

Michael Benvenuti1, Thomas An1, Emilie Amaro1

  • 1Vanderbilt University School of Medicine, Nashville, TN, USA.

The Orthopedic Clinics of North America
|March 25, 2017
PubMed

Insights

The acute phase response, crucial for healing, can cause complications in orthopedic patients when overactive. Modulating this response may improve outcomes for children with bone infections.

Area of Science:

  • Orthopedics
  • Immunology
  • Pediatrics

Background:

  • The acute phase response is the body's reaction to tissue injury.
  • Overactivation of the acute phase response leads to complications in orthopedic patients.
  • Musculoskeletal infections in children can cause persistent tissue injury, leading to increased risk.

Purpose of the Study:

  • To highlight the role of the acute phase response in musculoskeletal infections.
  • To emphasize the increased risk of complications in children with these infections.
  • To explore the potential of modulating the acute phase response for improved treatment.

Main Methods:

  • Review of existing literature on acute phase response and orthopedic infections.
  • Analysis of the mechanisms linking tissue injury, acute phase response, and complications.
  • Identification of potential therapeutic targets for modulating the acute phase response.

Main Results:

  • Excessive acute phase response activation is a key factor in orthopedic complications.
  • Children with musculoskeletal infections face a significantly higher risk of severe outcomes.
  • Persistent infection acts as a continuous stimulus for the acute phase response.

Conclusions:

  • The acute phase response plays a critical role in the pathophysiology of musculoskeletal infections.
  • Targeting strategies to modulate the acute phase response hold promise for preventing complications.
  • Further research into modulating the acute phase response could enhance treatment for pediatric orthopedic infections.

Keywords:
Acute phase responseMusculoskeletal infectionOsteomyelitisPyomyositisSeptic arthritis

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