Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Crown Ethers02:36

Crown Ethers

6.2K
Crown ethers are cyclic polyethers that contain multiple oxygen atoms, usually arranged in a regular pattern. The first crown ether was synthesized by Charles Pederson while working at DuPont in 1967. For this work, Pedersen was co-awarded the 1987 Nobel Prize in Chemistry. Crown ethers are named using the formula x-crown-y, where x is the total number of atoms in the ring and y is the number of ether oxygen atoms. The term 'crown' refers to the crown-like shape that these ether molecules...
6.2K
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation01:27

Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation

3.0K
Robinson annulation is a base-catalyzed reaction for the synthesis of 2-cyclohexenone derivatives from 1,3-dicarbonyl donors (such as cyclic diketones, β-ketoesters, or β-diketones) and α,β-unsaturated carbonyl acceptors. Named after Sir Robert Robinson, who discovered it, this reaction yields a six-membered ring with three new C–C bonds (two σ bonds and one π bond).
3.0K
Cycloaddition Reactions: Overview01:16

Cycloaddition Reactions: Overview

3.7K
Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
3.7K
Intramolecular Claisen Condensation of Dicarboxylic Esters: Dieckmann Cyclization01:13

Intramolecular Claisen Condensation of Dicarboxylic Esters: Dieckmann Cyclization

3.4K
Dieckmann cyclization is an intramolecular Claisen condensation of diesters. The reaction occurs in the presence of a base and generates a cyclic β-ketoester as the final product. Commonly, 1, 6 and 1, 7-diesters are preferred substrates for the reaction since the generated five, and six-membered cyclic β-keto esters are particularly more stable.
3.4K
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry01:29

Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry

6.3K
Diels–Alder reactions between cyclic dienes locked in an s-cis configuration and dienophiles yield bridged bicyclic products.
6.3K
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction01:16

[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction

13.4K
The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.
13.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of urinary metabolite biomarkers of psychiatric disorders using two-sample Mendelian randomization.

BMC psychiatry·2026
Same author

Tough and Rapidly Relaxing Hydrogels Via Programmable Crosslink Kinetics.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Oligomerisation and stereoselective polymerisation of alkenes and alkynes using pyridyl-based Al(iii) catalysts.

Chemical science·2026
Same author

Transient Au-Cl adlayers modulate the surface chemistry of gold nanoparticles during redox reactions.

Nature chemistry·2025
Same author

How many fluorophores are required to achieve AIE?

Chemical science·2025
Same author

Kinetic Locking of pH-Sensitive Complexes for Mechanically Responsive Polymer Networks.

Journal of the American Chemical Society·2025
Same journal

VOCs Adsorption and Exchange Properties in Bispidine-Based Mn(II) 1D CPs Made of Orthogonally Oriented Linear Chains.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Electrosynthesis of Glycine From Nitrate and Glyoxylic Acid Over a Bi<sub>2</sub>S<sub>3</sub> Nanosheets-Based Catalyst.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Symmetry Breaking in Achiral Porphyrins: Noncovalent Origins of Emergent Optical Activity.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Modulation of O<sub>2</sub> Affinity and Enzymatic Activity of Core‒Shell Structured Hemoglobin Nanoparticles.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Stepwise Synthesis of Tetrabenzotriazaporphyrins (TBTAPs) and Their Open 2- and 3-Ring Fragments.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Geometry-Based Neural-Network Prediction of Electron Localization Function Topology in Dense Hydrogen.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
See all related articles

Related Experiment Video

Updated: Mar 5, 2026

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
09:22

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

8.3K

DESolution of CD and CB Macrocycles.

Jade A McCune1, Susanna Kunz1, Magdalena Olesińska1

  • 1Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|March 25, 2017
PubMed
Summary
This summary is machine-generated.

Macrocyclic hosts like cyclodextrins (CDs) and cucurbit[n]urils (CB[n]s) show enhanced solubility in deep eutectic solvents (DES). These solvents maintain the essential host-guest properties for supramolecular chemistry applications.

Keywords:
cyclodextrinsdeep eutectic solventshost-guest chemistrymacrocyclessolubilization

More Related Videos

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

8.4K
Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction
10:39

Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction

Published on: August 23, 2018

8.4K

Related Experiment Videos

Last Updated: Mar 5, 2026

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
09:22

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

8.3K
Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

8.4K
Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction
10:39

Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction

Published on: August 23, 2018

8.4K

Area of Science:

  • Supramolecular Chemistry
  • Macrocyclic Chemistry

Background:

  • Supramolecular chemistry traditionally uses cyclodextrins (CDs) and cucurbit[n]urils (CB[n]s) in aqueous media.
  • Poor solubility, especially for CB[n]s, limits their application range.
  • Derivatization can improve solubility but may alter properties.

Purpose of the Study:

  • To investigate the dissolution of parent CDs and CB[n]s in deep eutectic solvents (DES).
  • To assess the impact of DES on the solubility and host-guest properties of these macrocycles.
  • To explore new solvation media for enhanced supramolecular chemistry.

Main Methods:

  • Dissolution experiments of alpha-, beta-, and gamma-cyclodextrins (CDs) and cucurbit[7]- and cucurbit[8]urils (CB[7], CB[8]) in various DES.
  • Characterization of host-guest properties in the new solvation medium.

Main Results:

  • Dramatic enhancement in solubility observed for larger macrocycles, specifically CB[7], CB[8], beta-CD, and gamma-CD in DES.
  • Parent macrocycles, including less soluble CB[n]s, exhibit improved dissolution in DES.
  • Host-guest complexation capabilities were retained in the DES medium.

Conclusions:

  • Deep eutectic solvents (DES) offer a promising alternative medium for dissolving macrocyclic hosts like CDs and CB[n]s.
  • Enhanced solubility in DES expands the utility of these macrocycles in supramolecular chemistry.
  • The host-guest properties are preserved, enabling new applications in diverse chemical environments.