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Characterization of Children With Recurrent Episodes of Stevens Johnson Syndrome

Daniel Olson1,2, Jordan Abbott3, Clara Lin1

  • 1University of Colorado School of Medicine, Aurora.

Journal of the Pediatric Infectious Diseases Society
|March 25, 2017
PubMed

Insights

Recurrent Stevens Johnson Syndrome (SJS) in children often involves mucus membranes with minimal skin issues. Mycoplasma infections and specific genetic markers like HLA-B27 are frequently observed in these cases.

Area of Science:

  • Pediatric Dermatology
  • Immunology
  • Infectious Diseases

Background:

  • Recurrent Stevens Johnson Syndrome (SJS) is a severe mucocutaneous reaction.
  • Understanding triggers and characteristics of recurrent SJS in pediatric populations is crucial.

Purpose of the Study:

  • To analyze the clinical features and potential associations of recurrent Stevens Johnson Syndrome (SJS) in children.
  • To identify commonalities among pediatric patients experiencing repeated SJS episodes.

Main Methods:

  • Retrospective chart review of pediatric patients diagnosed with recurrent SJS.
  • Data collection spanned from March 2013 to March 2016.
  • Analysis focused on patient demographics, clinical presentation, and associated factors.

Main Results:

  • Nine male children experienced 29 episodes of SJS or incomplete SJS.
  • The majority (88%) of patients were white.
  • Episodes predominantly affected mucous membranes with limited skin involvement.
  • Mycoplasma infections and HLA-B27/-B51 genetic markers were frequently identified.

Conclusions:

  • Recurrent SJS in children presents with characteristic mucocutaneous involvement.
  • Mycoplasma infections and specific HLA types may predispose children to recurrent SJS.
  • Further research into the immunological and infectious underpinnings of recurrent SJS is warranted.
Keywords:
Stevens Johnson syndromemucositismycoplasmapediatricrecurrent

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