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Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
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Cardiac involvement in granulomatosis with polyangiitis: a magnetic resonance imaging study of 31 consecutive

Grégory Pugnet1,2, Hervé Gouya3, Xavier Puéchal1

  • 1Service de Médecine Interne, Centre National de Référence Vascularites Nécrosantes et Sclérodermie Systémique, Hôpital Cochin, AP-HP, Université Paris Descartes, Paris.

Rheumatology (Oxford, England)
|March 25, 2017
PubMed

Insights

Cardiac MRI (CMRI) reveals significant heart abnormalities in 61% of granulomatosis with polyangiitis (GPA) patients, often subclinical. Early detection via CMRI is crucial for assessing cardiac lesions and prognosis in GPA.

Area of Science:

  • Cardiology
  • Radiology
  • Rheumatology

Background:

  • Cardiac involvement in granulomatosis with polyangiitis (GPA) is frequently subclinical and underestimated.
  • Assessing cardiac abnormalities in GPA is essential for patient management and prognosis.

Purpose of the Study:

  • To determine the prevalence and patterns of cardiac abnormalities in GPA patients using cardiac MRI (CMRI).
  • To evaluate the utility of CMRI in detecting subclinical cardiac involvement in GPA.

Main Methods:

  • Thirty-one patients with newly diagnosed or relapsing GPA underwent CMRI.
  • CMRI assessed morphology, function, resting perfusion, and late gadolinium enhancement (LGE).

Main Results:

  • 61% of GPA patients showed at least one CMRI abnormality.
  • Left ventricular ejection fraction (LVEF) was impaired in 13%, and regional wall motion abnormalities were seen in 35%.
  • Late gadolinium enhancement (LGE) was detected in 32% of patients, often nodular, and was associated with myocardial early contrast enhancement.

Conclusions:

  • CMRI is a sensitive tool for detecting cardiac involvement in GPA.
  • Non-invasive CMRI provides crucial clinical and prognostic information for GPA patients.
  • Early assessment of cardiac lesions and cumulative damage in GPA is possible with CMRI.
Abstract

Keywords:
ANCA-associated vasculitiscardiac magnetic resonance imagingcardiac manifestationsgranulomatosis with polyangiitis

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