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Updated: Mar 5, 2026
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Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
Published on: July 17, 2019
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Do the Side Effects of BRAF Inhibitors Mimic RASopathies?
Alicia Sfecci1, Alain Dupuy2, Monica Dinulescu1
1Department of Dermatology, Pontchaillou Hospital, CHU de Rennes, Rennes, France.
The Journal of Investigative Dermatology
|March 26, 2017
Summary
Targeted cancer therapies, like BRAF inhibitors, cause side effects distinct from chemotherapy. These drug-induced skin conditions (iatrogenic dermatoses) strikingly resemble genetic skin disorders (genodermatoses) in RASopathies.
Area of Science:
- Oncology
- Dermatology
- Genetics
Background:
- Targeted anticancer therapies offer improved cancer prognoses but have unique side effects.
- These side effects differ from traditional chemotherapy and stem from interference with specific oncogenic signaling pathways.
- Pathway interference can lead to effects mimicking genetic disorders.
Purpose of the Study:
- To compare the clinical effects of BRAF inhibitor treatment with genetic RASopathies.
- To investigate the overlap between drug-induced dermatoses and genodermatoses.
Main Methods:
- Clinical comparison of side effect profiles.
- Analysis of BRAF inhibitor-induced dermatoses.
- Comparison with congenital RASopathies and their associated genodermatoses.
Main Results:
- A striking overlap was observed between iatrogenic dermatoses from BRAF inhibitors and genodermatoses in RASopathies.
- Targeted therapies can induce effects mirroring congenital genetic disorders.
Conclusions:
- Understanding the link between targeted therapy side effects and genetic disorders deepens insight into drug mechanisms.
- This comparison aids in better understanding and managing side effects of novel cancer treatments.
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