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Updated: Mar 5, 2026

Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation
Published on: October 15, 2021
Local hemostatic matrix for endoscope-assisted removal of intracerebral hemorrhage is safe and effective
Hui-Tzung Luh1, Abel Po-Hao Huang1, Shih-Hung Yang1
1Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Background/Purpose:
Minimally invasive endoscope-assisted (MIE) evacuation of spontaneous intracerebral hemorrhage (ICH) is simple and effective, but the limited working space may hinder meticulous hemostasis and might lead to rebleeding. Management of intraoperative hemorrhage is therefore a critical issue of this study. This study presents experience in the treatment of patients with various types of ICH by MIE evacuation followed by direct local injection of FloSeal Hemostatic Matrix (Baxter Healthcare Corp, Fremont, CA, USA) for hemostasis.
Methods:
The retrospective nonrandomized clinical and radiology-based analysis enrolled 42 patients treated with MIE evacuation of ICH followed by direct local injection of FloSeal Hemostatic Matrix. Rebleeding, morbidity, and mortality were the primary endpoints. The percentage of hematoma evacuated was calculated from the pre- and postoperative brain computed tomography (CT) scans. Extended Glasgow Outcome Scale (GOSE) was evaluated at 6 months postoperatively.
Results:
Forty-two ICH patients were included in this study, among these, 23 patients were putaminal hemorrhage, 16 were thalamic ICH, and the other three were subcortical type. Surgery-related mortality was 2.4%. The average percentage of hematoma evacuated was 80.8%, and the rebleeding rate was 4.8%. The mean operative time was 102.7 minutes and the average blood loss was 84.9 mL. The mean postoperative GOSE score was 4.55 at 6-months' follow-up.
Conclusion:
This study shows that local application of FloSeal Hemostatic Matrix is safe and effective for hemostasis during MIE evacuation of ICH. In our experience, this shortens the operation time, especially in cases with intraoperative bleeding. A large, prospective, randomized trial is needed to confirm the findings.
Insights
Minimally invasive endoscope-assisted evacuation for intracerebral hemorrhage (ICH) using FloSeal Hemostatic Matrix effectively controlled bleeding. This technique improved hemostasis, reduced operative time, and showed promising outcomes in patients with spontaneous ICH.
Area of Science:
- Neurosurgery
- Minimally Invasive Surgery
- Hemorrhage Management
Background:
- Minimally invasive endoscope-assisted (MIE) evacuation is effective for spontaneous intracerebral hemorrhage (ICH).
- Limited working space in MIE can compromise hemostasis, potentially leading to rebleeding.
- Effective intraoperative hemorrhage management is critical for MIE success.
Purpose of the Study:
- To evaluate the safety and efficacy of FloSeal Hemostatic Matrix for hemostasis during MIE evacuation of ICH.
- To assess the impact of FloSeal on rebleeding rates, morbidity, and mortality.
- To analyze the effectiveness of MIE with FloSeal in various ICH types.
Main Methods:
- Retrospective analysis of 42 patients undergoing MIE evacuation of ICH followed by FloSeal injection.
- Primary endpoints included rebleeding, morbidity, and mortality.
- Hematoma evacuation percentage (CT scans) and Extended Glasgow Outcome Scale (GOSE) at 6 months were assessed.
Main Results:
- Surgery-related mortality was low at 2.4%.
- Average hematoma evacuation was 80.8% with a low rebleeding rate of 4.8%.
- Mean operative time was 102.7 minutes; mean postoperative GOSE score was 4.55 at 6 months.
Conclusions:
- Local application of FloSeal Hemostatic Matrix is safe and effective for hemostasis in MIE ICH evacuation.
- The technique appears to shorten operation time, particularly in cases with intraoperative bleeding.
- Further validation through large, prospective, randomized trials is recommended.
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