Related Experiment Video

Updated: Mar 5, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

14.6K

Transforming Growth Factor Beta Family in the Pathogenesis of Meningiomas

Mahlon D Johnson1

  • 1Division of Neuropathology, Department of Pathology, University of Rochester School of Medicine, Rochester, New York, USA.

World Neurosurgery
|March 28, 2017
PubMed
Abstract

Insights

Transforming growth factor beta (TGF-β) signaling is crucial in meningioma development. Targeting TGF-β pathways may offer new chemotherapy options for these brain tumors.

Area of Science:

  • Neuro-oncology
  • Molecular biology
  • Cancer research

Background:

  • Meningiomas constitute 36% of primary brain tumors.
  • Their pathogenesis is not fully understood, limiting effective chemotherapy development.
  • Growth factors and receptor kinases are implicated in meningioma growth.

Purpose of the Study:

  • To review evidence for the role of the transforming growth factor beta (TGF-β) family in meningiomas.
  • To explore TGF-β signaling as a potential therapeutic target.

Main Methods:

  • Literature review focusing on TGF-β, bone morphogenetic protein, and their mediators.
  • Analysis of signaling pathways in meningioma development and progression.

Main Results:

  • TGF-β's growth-inhibitory role in normal leptomeninges may be lost in meningiomas.
  • Loss of TGF-β and bone morphogenetic protein signaling components contributes to higher-grade meningiomas.
  • TGF-β type III receptor alterations are linked to meningioma progression.

Conclusions:

  • Disruptions in TGF-β family signaling are implicated in meningioma development and progression.
  • The TGF-β family presents potential new targets for meningioma chemotherapy.
  • Inhibitors of TGF-β-activated kinases could be a therapeutic strategy.
Keywords:
BMPMeningiomaSMADTGF-βTGF-β receptorsp44/42 MAPK

More Related Videos

Spheroid Assay to Measure TGF-β-induced Invasion09:18

Spheroid Assay to Measure TGF-β-induced Invasion

Published on: November 16, 2011

22.5K
Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling07:49

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling

Published on: August 3, 2018

11.9K

Related Concept Videos

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.8K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.0K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.8K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
8.2K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
6.0K
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
7.4K