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Integrating optical tweezers with up-converting luminescence: a non-amplification analytical platform for
Cheng-Yu Li1, Di Cao1, Chong-Yang Song1
1Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China. hwtang@whu.edu.cn.
Chemical Communications (Cambridge, England)
|March 28, 2017
Abstract:
We report a single-microsphere based imaging assay method by integrating up-converting luminescence with optical tweezers for detecting microRNA-21 sequences. This method achieves a competitive detection limit of 12 fM with good selectivity and no dedicated signal amplification designs.
