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Basics of Compounding with Dilutions and Concentrates
1International Journal of Pharmaceutical Compounding. lallen@ijpc.com.
International Journal of Pharmaceutical Compounding
|March 28, 2017
Summary
Pharmacists can now access new active pharmaceutical ingredient sources to meet upcoming United States Pharmacopeia <800> standards. Understanding drug strength and excipients is crucial for safe and effective medication compounding.
Area of Science:
- Pharmaceutical Sciences
- Compounding Pharmacy
Background:
- Pharmacists source active pharmaceutical ingredients (APIs) from various origins, including pure drugs, commercial dosage forms, dilutions, or concentrates.
- Adjustments to drug quantities are often required when APIs are not at full strength.
- The use of dilutions or concentrates is common for safety and quality assurance in compounding.
Purpose of the Study:
- To introduce novel sources of active pharmaceutical ingredients.
- To assist pharmacists in adhering to future United States Pharmacopeia <800> guidelines.
- To emphasize the importance of knowing API strength and excipient profiles.
Main Methods:
- Review of emerging API sources relevant to compounding.
- Analysis of implications for United States Pharmacopeia <800> compliance.
- Discussion of factors influencing API selection.
Main Results:
- Identification of new API sources available to compounding pharmacists.
- Highlighting the necessity of precise drug strength determination.
- Underscoring the significance of excipient awareness.
Conclusions:
- New API sources are available to support pharmacists in meeting evolving regulatory standards.
- Pharmacist vigilance regarding API strength and excipients is paramount for safe compounding.
- Proactive adaptation to new ingredient sources ensures quality patient care and compliance.
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