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Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Related Experiment Video

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Reduced Intestinal Motility, Mucosal Barrier Function, and Inflammation in Aged Monkeys.

E L Mitchell1, A T Davis, K Brass

  • 1Kylie Kavanagh, DVM, MS, MPH, Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27107, email: kkavanag@wakehealth.edu, phone: (336) 713 1745, fax: (336) 716 1515.

The Journal of Nutrition, Health & Aging
|March 28, 2017
PubMed
Summary
This summary is machine-generated.

Aging impairs intestinal function, leading to increased inflammation and reduced gut barrier integrity in older primates. These age-related changes occur independently of diet and microbiome shifts, suggesting targeted interventions could improve healthspan.

Keywords:
Intestinal microbial translocationaginginflammationmicrobiomemonkeymotility

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Area of Science:

  • Aging research
  • Gastroenterology
  • Primate physiology

Background:

  • Aging is associated with increased systemic inflammation and altered gut function.
  • Nutritional status and diet significantly impact gastrointestinal health.
  • Previous studies often confound age-related changes with environmental or disease factors.

Purpose of the Study:

  • To investigate age-related changes in general health and intestinal physiology in non-human primates.
  • To determine if intestinal changes occur independently of nutritional stressors.
  • To assess systemic inflammation, intestinal barrier function, and microbial translocation in young versus old primates.

Main Methods:

  • Evaluation of vervet monkeys (Chlorcebus aethiops sabaeus) with comparable life histories and environments.
  • Measurement of health phenotypes, circulating cytokines, and biomarkers of microbial translocation (MT).
  • Characterization of intestinal motility, permeability, and fecal microbiomes in subsets of animals.

Main Results:

  • Older monkeys exhibited higher systemic inflammation and impaired intestinal barrier function compared to younger monkeys.
  • Significant reductions in intestinal motility were observed in older primates.
  • These age-related intestinal changes occurred without substantial alterations in fecal microbiome composition.

Conclusions:

  • Deteriorating intestinal function is a characteristic of normal aging in primates.
  • Age-related intestinal dysfunction may contribute to the inflammatory burden observed in aging populations.
  • Interventions targeting intestinal motility and barrier function may enhance health during aging.