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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

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Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

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A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Vitamin D Supplementation in Nursing Home Residents: Randomized Single Cholecalciferol Loading Protocol vs.

C Delomas1, M Hertzog, T Vogel

  • 1Lang Pierre-Olivier, Geriatric medicine and Geriatric rehabilitation division, Department of medicine, University Hospital of Lausanne (CHUV), Chemin de Mont Paisible 16, MP16/04/414, CH-1011 Lausanne, Switzerland, E-Mail: Pierre Olivier.Lang@chuv.ch; Tel: +41.(0)21.314.37.04; Fax: +41.(0)21.314.17.20.

The Journal of Nutrition, Health & Aging
|March 28, 2017
PubMed
Summary

A single cholecalciferol loading dose effectively and safely raised vitamin D levels in nursing home residents. This approach is as effective as tailored regimens for normalizing vitamin D status in this population.

Keywords:
Vitamin D statusnursing home residentsvitamin D deficiencyvitamin D loading dosevitamin D supplementation

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Area of Science:

  • Gerontology
  • Nutritional Science
  • Clinical Medicine

Background:

  • Vitamin D deficiency is prevalent in nursing home residents.
  • Adequate vitamin D is crucial for bone health and overall well-being in the elderly.
  • Previous supplementation protocols may not be optimal for this vulnerable group.

Purpose of the Study:

  • To evaluate the efficacy and safety of a single cholecalciferol loading protocol.
  • To compare this protocol against an individualized regimen in nursing home residents.
  • To assess the impact on vitamin D (25(OH)VitD) levels and safety markers.

Main Methods:

  • A randomized, single-blind, controlled study was conducted in a nursing home.
  • Residents received either a fixed loading dose regimen or an individualized regimen based on baseline 25(OH)VitD levels.
  • Serum levels of 25(OH)VitD, calcium, phosphorus, parathyroid hormone, alkaline phosphatase, and creatinine were measured.

Main Results:

  • Both protocols successfully normalized 25(OH)VitD levels, with 100% reaching ≥20ng/mL and over 88% reaching ≥30ng/mL.
  • The loading dose group showed a significantly higher mean 25(OH)VitD level (50.2 ng/mL) compared to the control group (35.8 ng/mL).
  • No biological adverse effects were observed in either group.

Conclusions:

  • A single cholecalciferol loading protocol is a safe and effective alternative to tailored regimens for rapidly improving vitamin D status in nursing home residents.
  • This loading protocol simplifies vitamin D supplementation initiation in this population.
  • The findings suggest that intensive, individualized dosing may not be necessary for initial vitamin D repletion.