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Published on: July 5, 2019
Malignant acrospiroma: a case report in the era of next generation sequencing
Maria Diab1, Ali Gabali2, Muaiad Kittaneh3
1Department of Internal Medicine, Wayne State University, School of Medicine, Detroit, MI, USA. mdiab@med.wayne.edu.
Background:
Malignant acrospiroma is a rare tumor of the eccrine sweat glands accounting for around 6% of all malignant eccrine tumors. Typically, it presents as large ulcerated nodules, and diagnosis can be challenging as it has great overlap with its benign counterpart.
Case Presentation:
We herein report a case of acral malignant acrospiroma, initially treated with surgical excision and adjuvant radiotherapy. After metastatic disease was confirmed, subject received multiple lines of chemo- as well as targeted therapy. Genomic testing was also done using next generation sequencing.
Conclusion:
To the best of our knowledge, this is the first case of acral malignant acrospiroma with reported next generation sequencing results.
