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Updated: Mar 5, 2026

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
Published on: November 21, 2025
Multimodal analgesia and regional anaesthesia
C Tornero Tornero1, L E Fernández Rodríguez2, J Orduña Valls3
1Unidad del Dolor, Servicio de Anestesiología, Hospital Clínico Universitario de Valencia, Valencia, España; Departamento de Anatomía Humana, Universitat de Valencia, Valencia, España.
Multimodal analgesia, combining techniques like regional anesthesia, enhances pain relief and reduces side effects. Ultrasound guidance enables advanced regional anesthesia techniques for better pain management.
Area of Science:
- Anesthesiology
- Pain Management
- Surgical Care
Background:
- Multimodal analgesia offers superior pain relief with fewer adverse effects by combining analgesic strategies.
- Regional anesthesia is crucial for multimodal analgesia, modulating nociceptive stimuli at the central level.
- Traditional regional anesthesia relied on neurostimulation or anatomical landmarks, limiting technique development.
Purpose of the Study:
- To highlight the role of regional anesthesia in multimodal analgesia.
- To discuss the impact of ultrasound technology on advancing regional anesthesia techniques.
- To emphasize the importance of combining regional anesthesia with other analgesic modalities.
Main Methods:
- Review of regional anesthesia techniques, including peripheral and central blocks (single dose or infusion).
- Integration of ultrasound guidance for enhanced precision and expanded technique possibilities.
- Combination therapy involving regional anesthesia and other analgesic routes.
Main Results:
- Regional anesthesia techniques effectively modulate nociceptive stimuli.
- Ultrasound has facilitated novel regional anesthesia procedures previously not feasible.
- Combined approaches allow for reduced individual drug doses and potentially synergistic analgesic effects.
Conclusions:
- Multimodal analgesia, particularly with regional anesthesia, is key to effective pain management.
- Ultrasound-guided regional anesthesia expands therapeutic options and improves procedural success.
- Synergistic effects are achievable by combining regional anesthesia with other analgesic methods, optimizing patient outcomes.
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