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Inositol and In Vitro Fertilization with Embryo Transfer
G Simi1, A R Genazzani1, M E R Obino1
1Division of Obstetrics and Gynecology Oncology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
International Journal of Endocrinology
|March 29, 2017
Summary
Inositol supplementation, particularly myo-inositol (MYO), enhances in vitro fertilization (IVF) outcomes by improving ovarian function, oocyte quality, and pregnancy rates. It also reduces the need for gonadotropins during stimulation and improves sperm parameters.
Area of Science:
- Reproductive endocrinology and infertility.
- Biochemistry of metabolic pathways.
- Assisted reproductive technologies.
Background:
- Inositol, especially myo-inositol (MYO), is investigated for its role in improving metabolic and reproductive health.
- Insulin resistance negatively impacts fertility and outcomes of in vitro fertilization (IVF).
- Prestimulation therapy with MYO is explored to enhance IVF cycle success rates.
Purpose of the Study:
- To evaluate the efficacy of inositol supplementation in infertile patients undergoing IVF.
- To assess the impact of MYO on ovarian response, oocyte and embryo quality, and pregnancy rates.
- To determine if inositol reduces the required dosage of gonadotropins in IVF protocols.
Main Methods:
- Inositol (MYO) supplementation initiated three months prior to ovarian stimulation for IVF.
- Monitoring hormonal responses, including FSH requirements and 17beta-estradiol levels.
- Assessing oocyte quality, embryo development, and pregnancy outcomes.
- Evaluating sperm parameters in patients with oligoasthenoteratozoospermia.
Main Results:
- Inositol supplementation significantly improved hormonal responses during ovarian stimulation.
- Reduced need for follicle-stimulating hormone (FSH) and resulted in optimal follicle development.
- Enhanced oocyte quality, decreasing degenerated and immature oocytes, leading to better embryo quality.
- Improved pregnancy and embryo rates observed with MYO therapy.
- Positive effects on sperm parameters in affected males.
Conclusions:
- Inositol (MYO) supplementation is a promising prestimulation therapy for infertile patients undergoing IVF.
- MYO improves key markers of ovarian function, oocyte and embryo quality, and pregnancy outcomes.
- It offers a potential strategy to reduce gonadotropin dosage and improve reproductive success.
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