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Corn-based vaccines: current status and prospects.

Sergio Rosales-Mendoza1, Cristhian Sández-Robledo2, Bernardo Bañuelos-Hernández3

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Summary
This summary is machine-generated.

Corn shows promise for producing and delivering oral vaccines. This review explores current progress and future directions for plant-based vaccine technology using corn as a key biomass source.

Keywords:
Gamma zein promoterMaizeMolecular farmingOral immunizationSeedVaccineVacuole targetingZea mays

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Area of Science:

  • Biotechnology
  • Plant molecular biology
  • Vaccinology

Background:

  • Corn is a significant biomass source for various applications, including food and fuel.
  • Plant-based vaccine technology utilizes plants for the production and delivery of vaccines.
  • Corn has been investigated for vaccine development since the inception of this technology.

Purpose of the Study:

  • To provide an updated outlook on corn as a host for vaccine production and oral delivery.
  • To highlight the expression strategies employed in corn-based vaccine development.
  • To discuss future perspectives for this field.

Main Methods:

  • Review of existing literature on corn-based vaccine production.
  • Analysis of expression strategies used in genetically modified corn for vaccine development.
  • Evaluation of clinical and preclinical data for corn-derived vaccine candidates.

Main Results:

  • Over a dozen pathogens have been targeted using corn-based vaccine technology.
  • A vaccine prototype against enterotoxigenic Escherichia coli (ETEC) has undergone Phase I clinical trials.
  • Several other vaccine candidates for bacterial and viral diseases are in preclinical development.

Conclusions:

  • Corn is a viable and attractive host for the development of edible vaccines.
  • The field of plant-based vaccines in corn demonstrates significant progress and future potential.
  • Further research into expression strategies and clinical evaluation is warranted.