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B1 -sensitivity analysis of quantitative magnetization transfer imaging.

Mathieu Boudreau1, Nikola Stikov2,3, G Bruce Pike1,4

  • 1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

Magnetic Resonance in Medicine
|March 29, 2017
PubMed
Summary
This summary is machine-generated.

Quantitative magnetization transfer (qMT) parameters are sensitive to B1 inaccuracies. Using variable flip angle (VFA) T1 mapping makes the pool-size ratio (F) more robust against these errors, potentially allowing B1 mapping to be omitted.

Keywords:
B1 mappingT1 mappingquantitative magnetization transfersensitivity analysis

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Area of Science:

  • Magnetic Resonance Imaging
  • Quantitative Imaging

Background:

  • Quantitative magnetization transfer (qMT) is a powerful technique for characterizing tissue microstructure.
  • B1 field inaccuracies can significantly impact the accuracy of qMT parameter estimation.
  • T1 mapping techniques vary in their dependency on B1 field accuracy.

Purpose of the Study:

  • To evaluate the sensitivity of qMT fitted parameters to B1 inaccuracies.
  • To compare B1-dependency between B1-independent and B1-dependent T1 mapping techniques for qMT analysis.

Main Methods:

  • Investigated B1-sensitivity of qMT using inversion recovery (IR) (B1-independent) and variable flip angle (VFA) (B1-dependent) T1 mapping.
  • Performed numerical simulations and Z-spectra sensitivity analysis.
  • Acquired data from healthy subjects at 3T using three different B1 imaging techniques.

Main Results:

  • Simulations showed pool-size ratio (F) errors of -3% to 7% for VFA and -40% to >100% for IR with typical brain B1 variations (±30%).
  • Healthy subject data revealed high correlations (ρ=0.97/0.81 for VFA/IR) between F and B1 maps.
  • VFA T1 mapping demonstrated greater robustness against B1 inaccuracies compared to IR.

Conclusions:

  • qMT B1-sensitivity is substantially influenced by the T1 mapping method's B1-dependency.
  • The pool-size ratio (F) is more robust to B1 inaccuracies when using VFA T1 mapping.
  • B1 mapping may be omitted in qMT studies employing VFA T1 mapping without significant bias in F.