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Updated: Mar 5, 2026

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR
08:30

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR

Published on: May 16, 2012

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MicroRNA-455-3p functions as a tumor suppressor by targeting eIF4E in prostate cancer

Yongxiang Zhao1, Mingyu Yan2, Ye Yun1

  • 1Department of Urinary Surgery of The Fourth Hospital of Baotou, Baotou, Inner Mongolia, P.R. China.

Oncology Reports
|March 29, 2017
PubMed

Insights

MicroRNA-455-3p (miR-455-3p) is downregulated in prostate cancer, promoting tumor growth. Targeting eIF4E, miR-455-3p acts as a tumor suppressor, offering potential therapeutic strategies for prostate cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are key regulators in cancer development.
  • Aberrant expression of microRNA-455-3p (miR-455-3p) is observed in tumors, but its role in prostate cancer is unclear.

Purpose of the Study:

  • To investigate the function of miR-455-3p in prostate cancer.
  • To identify the molecular targets and mechanisms of miR-455-3p in prostate tumorigenesis.

Main Methods:

  • Analysis of miR-455-3p expression in prostate cancer cell lines and tissues.
  • In vitro and in vivo gain-of-function and loss-of-function studies.
  • Bioinformatics analysis and Luciferase reporter assays to identify miR-455-3p targets.

Main Results:

  • miR-455-3p was significantly downregulated in prostate cancer.
  • Overexpression of miR-455-3p inhibited prostate cancer cell proliferation in vitro and in vivo.
  • miR-455-3p directly targets and suppresses eukaryotic translation initiation factor 4E (eIF4E).
  • miR-455-3p inhibits cap-dependent translation and prostate cancer cell proliferation by targeting eIF4E.

Conclusions:

  • miR-455-3p functions as a tumor suppressor in prostate cancer.
  • The miR-455-3p/eIF4E axis is a critical regulator of prostate cancer progression.
  • miR-455-3p represents a potential therapeutic target for prostate cancer treatment.

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