Apheresis in food allergies

Area of Science:

• Immunology
• Allergology
• Medical Technology

Background:

• Rising prevalence of IgE-mediated food allergy and anaphylaxis globally.
• Current therapies (elimination diets, Oral ImmunoTherapy, biologics) may be limited by high serum IgE levels.
• Decreasing IgE is a rational therapeutic strategy.

Purpose of the Study:

• To review the rationale and advantages of immunoapheresis for managing allergic diseases.
• To evaluate immunoapheresis as a method to reduce IgE levels.
• To explore its potential in treating food allergy and atopic dermatitis.

Main Methods:

• Review of emerging data on immunoapheresis for allergic diseases.
• Focus on IgE-specific adsorbers versus non-specific immunoglobulin removal.
• Analysis of clinical outcomes in atopic dermatitis and multiple food allergy (MFA).

Main Results:

• IgE-specific adsorbers are recently approved, complementing non-specific methods.
• Immunoapheresis shows potential benefit in atopic dermatitis.
• IgE-selective apheresis may reduce anaphylaxis risk in MFA and facilitate Omalizumab treatment.

Conclusions:

• Immunoapheresis is a promising approach for managing conditions with high IgE.
• Further prospective studies are required to establish efficacy, tolerability, and cost-effectiveness.
• This therapy could expand treatment options for severe food allergy.