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Pushing Yap into the Nucleus with Shear Force
Jason Kuan Han Lai1, Didier Y R Stainier1
1Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.
Developmental Cell
|March 29, 2017
Abstract:
Endothelial cells line blood vessels and experience shear stress from blood flow. In this issue of Developmental Cell, Nakajima and colleagues (2017) show that in zebrafish Yap responds to blood flow by translocating into the nucleus, where it drives a genetic program to maintain vascular stability.