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Urinary glutamine/glutamate ratio as a potential biomarker of pediatric chronic intestinal pseudo-obstruction

Jun-Kai Yan1,2,3, Ke-Jun Zhou1,2,3, Jian-Hu Huang1

  • 1Department of Pediatric Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Rd, Shanghai, 200092, China.

Orphanet Journal of Rare Diseases
|March 30, 2017
PubMed

Insights

Diagnosing chronic intestinal pseudo-obstruction (CIPO) in children is challenging. A new urinary biomarker, the glutamine to glutamic acid ratio, shows promise for differentiating CIPO from short bowel syndrome (SBS).

Area of Science:

  • Pediatric Gastroenterology
  • Biomarker Discovery
  • Gastrointestinal Motility Disorders

Background:

  • Chronic intestinal pseudo-obstruction (CIPO) is a rare pediatric motility disorder with severe outcomes.
  • CIPO diagnosis is challenging due to overlapping symptoms with conditions like short bowel syndrome (SBS).
  • Reliable and accessible diagnostic markers for CIPO are needed.

Discussion:

  • This study investigated the potential of urinary amino acid ratios as diagnostic markers for CIPO.
  • The ratio of glutamine to glutamic acid was identified as a promising candidate biomarker.
  • This ratio may help differentiate CIPO from SBS in pediatric patients.

Key Insights:

  • The glutamine/glutamic acid ratio demonstrated an area under the ROC curve of 0.83.
  • A cutoff value of 7.04 achieved 65% sensitivity and 92% specificity in distinguishing CIPO from SBS.
  • This urinary biomarker offers a potential tool for improving CIPO diagnosis.

Outlook:

  • Further validation studies are required to confirm the utility of this biomarker in clinical practice.
  • This discovery could lead to earlier and more accurate diagnosis of CIPO in children.
  • Development of novel diagnostic strategies for rare gastrointestinal motility disorders is crucial.

Keywords:
BiomarkerChronic intestinal pseudo-obstructionShort bowel syndromeUrinary glutamine/glutamate ratios

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