Light-Addressable Organic Photoelectrochemical Transistor: Toward Multiplex Screening of Inhibitor Drugs

While light-addressable detection has been increasingly studied, no effort has been devoted to study its potential in newly emerging organic photoelectrochemical transistors (OPECTs). Herein, we propose and devise the first light-addressable OPECT, which is exemplified by a nine-channel device with three "detecting" channels for benchmarking the activity of thrombin and six "screening" channels for the parallel study of six inhibitor drugs. Specifically, the photoactive and conductive metal-organic framework heterojunction is harnessed to photogate an accumulated-type organic transistor. By integrating the photogate with the alkaline phosphatase (ALP)-labeled peptides to recognize thrombin, the ALP-enabled biocatalytic precipitation reaction can lead to the inhibition of interfacial charge transfer and thus a weakened gating effect. Based on such an effect, the inhibition efficiencies of six thrombin inhibitor drugs are then well differentiated. This work features light-addressable OPECT bioanalysis.