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Related Concept Videos

The Arch of Aorta01:10

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The aorta is the largest artery in the human body. It originates from the left ventricle of the heart and extends down to the abdomen, where it splits into two smaller arteries. Structurally, it can be divided into four main parts: the ascending aorta, the aortic arch, the thoracic aorta, and the abdominal aorta.
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Related Experiment Video

Updated: Mar 5, 2026

Visualization and Analysis of Pharyngeal Arch Arteries using Whole-mount Immunohistochemistry and 3D Reconstruction
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Morphological Analysis of Healthy Aortic Arch.

M Boufi1, C Guivier-Curien2, A D Loundou3

  • 1Aix-Marseille Université, IFSTTAR, UMR T24, 13916, Marseille, France; APHM, University Hospital Nord, Department of Vascular Surgery, 13915, Marseille, France; Aix-Marseille Université, CNRS, Ecole Centrale Marseille, IRPHE UMR 7342, 13384, Marseille, France.

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
|March 30, 2017
PubMed
Summary

This study developed a standardized protocol to analyze thoracic aorta morphology in healthy individuals. It found that aorta shape significantly changes with age and differs between sexes, impacting endovascular treatments.

Keywords:
AdultAge factorsAnatomyAortic archComputed tomographyHumansSex factors

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Area of Science:

  • Medical Imaging
  • Cardiovascular Anatomy
  • Biomechanical Engineering

Background:

  • Thoracic aorta morphology is crucial for cardiovascular health and endovascular interventions.
  • Standardized protocols for arch morphology assessment are lacking.
  • Understanding age and sex variations is vital for personalized medicine.

Purpose of the Study:

  • To establish a standardized protocol for thoracic aorta arch morphology analysis in a healthy population.
  • To investigate the influence of age and sex on thoracic aorta arch morphology.
  • To provide objective data for improving endovascular arch treatments.

Main Methods:

  • Retrospective analysis of computed tomography (CT) imaging from 123 healthy subjects.
  • Application of a standardized protocol using Matlab scripts to calculate morphometric and geometric parameters.
  • Statistical analysis including Student's t-test, Mann-Whitney test, and regression analysis to assess age and sex effects.

Main Results:

  • Significant age-related changes in aorta morphology, including expansion and heterogeneous stretching due to posterior arch elongation.
  • Aging was associated with decreased tortuosity index (TI), increased assimilated curvature radius (CRi), and increased attachment zone angles.
  • Sex-specific differences were observed: men had longer total arch length and higher CRarch, while women had lower zone 3 attachment angles.

Conclusions:

  • A standardized protocol for thoracic aorta arch morphology has been successfully developed and applied.
  • Objective evidence demonstrates significant age-related evolution and sex-related variations in thoracic aorta arch morphology.
  • These findings are critical for optimizing endovascular treatment strategies for thoracic aorta pathologies.