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Serum ZAG Levels Were Associated with eGFR Mild Decrease in T2DM Patients with Diabetic Nephropathy.

Lingling Xu1, Weihong Yu2, Meng Niu3

  • 1Key Laboratory of Endocrinology of National Health and Family Planning Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China.

International Journal of Endocrinology
|March 30, 2017
PubMed
Summary
This summary is machine-generated.

Serum zinc-α2-glycoprotein (ZAG) levels are linked to reduced kidney function in type 2 diabetes. Higher ZAG may indicate a higher risk of mild kidney function decline in T2DM patients.

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Area of Science:

  • Endocrinology
  • Nephrology
  • Biochemistry

Background:

  • Type 2 diabetes mellitus (T2DM) is a global health concern associated with various complications.
  • Kidney function, assessed by estimated glomerular filtration rate (eGFR), is crucial in managing T2DM.
  • Serum zinc-α2-glycoprotein (ZAG) is a protein with emerging roles in metabolic and inflammatory processes.

Purpose of the Study:

  • To investigate the association between serum ZAG levels and mild decreases in eGFR among T2DM patients.
  • To identify potential clinical factors modifying this relationship.

Main Methods:

  • A cohort of 438 T2DM patients was recruited.
  • Demographic, anthropometric, and biochemical data were collected.
  • Serum ZAG levels were quantified using ELISA kits.

Main Results:

  • Patients with higher serum ZAG levels showed a significantly higher prevalence of mildly decreased eGFR (<90 mL/min/1.73 m²).
  • Elevated ZAG levels were independently associated with an increased probability of reduced eGFR (OR=1.94).
  • This association was more pronounced in patients with higher urinary albumin-to-creatinine ratio (uACR) and larger waist circumference (WC), particularly in women.

Conclusions:

  • Serum ZAG levels are significantly associated with mild eGFR reduction in T2DM patients.
  • High serum ZAG may serve as a potential biomarker for early kidney dysfunction in T2DM.
  • Further research is warranted to elucidate the causal mechanisms and clinical implications.