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Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
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High serum lactate level may predict death within 24 hours.

Arnon Blum1, Abd Almajid Zoubi2, Shiran Kuria2

  • 1Department of Medicine, Baruch Padeh Poriya Hospital, Bar Ilan University, Lower Galilee 15208, Israel, Tel: +972-4-665-2688.

Open Medicine (Warsaw, Poland)
|March 30, 2017
PubMed
Summary
This summary is machine-generated.

Arterial blood lactate levels on admission are a strong predictor of unexpected death within 24 hours for hospitalized patients. Monitoring lactate can aid in risk assessment for patients with suspected sepsis.

Keywords:
LactateSIRS

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Area of Science:

  • Critical Care Medicine
  • Biochemistry
  • Clinical Pathology

Background:

  • Unexpected death within 24 hours of hospital admission presents a significant clinical challenge.
  • Diagnosing and preventing rapid mortality in emergency room patients remains an enigma.
  • Identifying independent factors influencing early clinical outcomes is crucial.

Purpose of the Study:

  • To identify independent factors predicting clinical outcomes within the first 24 hours of hospital admission.
  • To investigate the role of specific clinical and biochemical parameters in early mortality.
  • To establish predictive markers for sudden death in admitted patients.

Main Methods:

  • Retrospective study of patients admitted over six years.
  • Comparison of 43 patients who died within 24 hours against 6055 controls.
  • Analysis of parameters including age, temperature, SIRS criteria, arterial blood lactate, and pH.

Main Results:

  • Sepsis with SIRS was common in patients dying within 24 hours.
  • Deceased patients were older, with higher lactate and lower pH.
  • Lactate was the strongest independent predictor of 24-hour mortality (OR 1.366), followed by age and pH.

Conclusions:

  • Arterial blood lactate level on admission is a significant independent predictor of death within 24 hours.
  • Older age is also an independent factor; low pH is significant primarily in males.
  • Arterial blood lactate is proposed as a biomarker for risk assessment and early mortality prediction in suspected sepsis.