Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

8.3K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
8.3K
Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

1.4K
Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
1.4K
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

1.6K
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
1.6K
Neural Regulation01:37

Neural Regulation

43.8K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.8K
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

1.3K
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
1.3K
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

1.9K
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical efficacy and safety of icodextrin dialysate for overnight dwell in continuous ambulatory peritoneal dialysis: A prospective self-controlled study.

The Journal of international medical research·2026
Same author

The impact of acupuncturists' experience level on the efficacy of acupuncture for functional dyspepsia: an exploratory secondary analysis of a randomized clinical trial.

Frontiers in medicine·2026
Same author

Dysregulation of the HSF1-Mediated UPR<sup>mt</sup> Pathway in Colonic Smooth Muscle Cells Drives Motility Dysfunction in Functional Constipation.

Biomolecules·2026
Same author

Spatial Tail Design in Ionizable Lipids Enhances the Safety and Efficacy of mRNA Delivery.

Small methods·2026
Same author

Multiscale structural connectome eigenmodes constrain human brain functional dynamics.

Communications biology·2026
Same author

IL17 signaling promotes oocyte developmental competence acquisition during maturation.

Cellular & molecular biology letters·2026
Same journal

Neuromelanin-sensitive MRI for identifying dopamine transporter imaging abnormality risk in idiopathic rapid eye movement sleep behavior disorder.

Brain imaging and behavior·2026
Same journal

Association between amygdala subregions and non-motor symptoms in Parkinson's disease: a fixel-based analysis.

Brain imaging and behavior·2026
Same journal

Normalization method for relative cerebral blood flow influences sex and cognitive status effects in nondemented older adults.

Brain imaging and behavior·2026
Same journal

Lack of association of the 5-HTTLPR polymorphism and brain serotonin transporter or receptor in healthy individuals: bayesian and frequentist meta-analyses.

Brain imaging and behavior·2026
Same journal

Prediction modeling in transdiagnostic risk: results from the PROCAN study.

Brain imaging and behavior·2026
Same journal

Impact of modifiable lifestyle factors on dementia subtypes and brain structural changes across KDIGO risk categories in the UK biobank.

Brain imaging and behavior·2026
See all related articles

Related Experiment Video

Updated: Mar 5, 2026

The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management
06:40

The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management

Published on: June 29, 2019

7.1K

Abnormal brain structure implicated in patients with functional dyspepsia.

Peng Liu1,2, Geliang Wang3,4, Fang Zeng5

  • 1Life Sciences Research Center, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, China. liupengphd@gmail.com.

Brain Imaging and Behavior
|March 30, 2017
PubMed
Summary
This summary is machine-generated.

Functional dyspepsia (FD) patients show reduced cortical thickness in brain regions controlling sensation and cognition. These structural brain changes correlate with symptom severity, suggesting they may result from living with FD.

Keywords:
Cortical thicknessFunctional dyspepsiaMRISubcortical volume

More Related Videos

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

46.6K
In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats
09:36

In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats

Published on: March 23, 2022

2.8K

Related Experiment Videos

Last Updated: Mar 5, 2026

The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management
06:40

The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management

Published on: June 29, 2019

7.1K
Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

46.6K
In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats
09:36

In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats

Published on: March 23, 2022

2.8K

Area of Science:

  • Neuroimaging
  • Gastroenterology
  • Brain-Gut Axis Research

Background:

  • Dysfunctional brain-gut interactions are implicated in functional dyspepsia (FD) pathophysiology.
  • Limited research exists on brain structural abnormalities in FD patients.

Purpose of the Study:

  • To identify differences in cortical thickness and subcortical volume between FD patients and healthy controls (HCs).
  • To explore the relationship between structural brain abnormalities and clinical symptoms in FD.

Main Methods:

  • Structural magnetic resonance imaging (3T MRI) was performed on 69 FD patients and 49 HCs.
  • Cortical thickness and subcortical volumes were compared between groups.
  • Regression analysis examined correlations between structural changes and clinical symptoms.

Main Results:

  • FD patients exhibited decreased cortical thickness in multiple brain regions, including the prefrontal cortex, cingulate cortex, insula, and parietal cortex.
  • Negative correlations were found between symptom scores (Nepean Dyspepsia Index) and cortical thickness in areas like the medial prefrontal cortex and insula.
  • Disease duration correlated negatively with cortical thickness in the ventrolateral prefrontal cortex and insula.

Conclusions:

  • FD patients present with structural brain abnormalities in regions vital for sensory processing, motor control, pain modulation, and cognitive functions.
  • The observed brain structural changes and their correlation with symptoms suggest they may be a consequence of the chronic condition of FD.