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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
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Stress-induced alteration of left ventricular eccentricity: An additional marker of multivessel CAD

Alessia Gimelli1, Riccardo Liga2, Assuero Giorgetti1

  • 1Fondazione Toscana G. Monasterio, Pisa, Italy.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|March 30, 2017
PubMed

Insights

Abnormal left ventricular eccentricity index (EI) during stress myocardial perfusion imaging (MPI) can indicate significant coronary artery disease (CAD). Lower post-stress EI values may help identify patients with multivessel CAD.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Cardiac Remodeling

Background:

  • Abnormal left ventricular (LV) eccentricity index (EI) signifies adverse cardiac remodeling.
  • The interplay between stress-induced EI changes and cardiac parameters requires further investigation.

Purpose of the Study:

  • To assess the association between LV EI and coronary artery disease (CAD) burden.
  • To evaluate LV EI in patients undergoing myocardial perfusion imaging (MPI).

Main Methods:

  • 343 patients underwent MPI and coronary angiography.
  • LV ejection fraction (EF) and EI were calculated from gated stress MPI images.
  • Patients were categorized into normal coronary arteries, single-vessel CAD, and multivessel CAD groups.

Main Results:

  • Post-stress EI was significantly lower in patients with multivessel CAD compared to those with normal or single-vessel CAD (P=0.001).
  • This association was significant in patients who underwent an exercise stress test.
  • A lower post-stress EI predicted multivessel CAD presence in the exercise stress test subgroup (P=0.039).

Conclusions:

  • Stress-induced alterations in LV EI detected by MPI can reveal the presence of multivessel CAD.
  • LV EI serves as a potential imaging biomarker for significant coronary artery disease.
Abstract

Keywords:
CZTLeft ventricular remodelingeccentricity indexejection fractiongated SPECT

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