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Severe Asthma in Children

Bradley E Chipps1, Neil G Parikh2, Sheena K Maharaj2

  • 1Capital Allergy and Respiratory Disease Center, 5609 J Street, Suite C, Sacramento, CA, 95819, USA. bchipps@capitalallergy.com.

Current Allergy and Asthma Reports
|March 30, 2017
PubMed

Insights

Severe childhood asthma onset is early, influenced by viral infections and atopy. Biomarkers may predict treatment response, but individual patient variability is significant in managing this condition.

Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology
  • Asthma Pathophysiology

Background:

  • Severe childhood asthma presents unique diagnostic and therapeutic challenges.
  • Early identification and understanding of disease triggers are crucial for effective management.

Purpose of the Study:

  • To comprehensively characterize, diagnose, evaluate, and treat severe asthma in children.
  • To explore factors influencing the onset and variability of treatment response in pediatric severe asthma.

Main Methods:

  • Review of current literature on severe childhood asthma.
  • Analysis of physiologic and clinical presentations.
  • Evaluation of biomarker utility in predicting treatment response.

Main Results:

  • Severe asthma onset in children is often early.
  • Viral infection severity and atopic status are key predictors of onset.
  • Biomarkers show potential for predicting treatment response, yet significant patient variability exists.

Conclusions:

  • Effective management of severe childhood asthma requires a multifaceted approach.
  • Further research into personalized treatment strategies based on biomarkers and individual patient factors is warranted.
Abstract

Keywords:
Biologic therapyBiomarkersChildhood asthmaPharmacologic therapySevere asthma

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