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Related Concept Videos

Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
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Related Experiment Video

Updated: Mar 5, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

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Severe Asthma in Children.

Bradley E Chipps1, Neil G Parikh2, Sheena K Maharaj2

  • 1Capital Allergy and Respiratory Disease Center, 5609 J Street, Suite C, Sacramento, CA, 95819, USA. bchipps@capitalallergy.com.

Current Allergy and Asthma Reports
|March 30, 2017
PubMed
Summary

Severe childhood asthma onset is early, influenced by viral infections and atopy. Biomarkers may predict treatment response, but individual patient variability is significant in managing this condition.

Keywords:
Biologic therapyBiomarkersChildhood asthmaPharmacologic therapySevere asthma

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Last Updated: Mar 5, 2026

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Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology
  • Asthma Pathophysiology

Background:

  • Severe childhood asthma presents unique diagnostic and therapeutic challenges.
  • Early identification and understanding of disease triggers are crucial for effective management.

Purpose of the Study:

  • To comprehensively characterize, diagnose, evaluate, and treat severe asthma in children.
  • To explore factors influencing the onset and variability of treatment response in pediatric severe asthma.

Main Methods:

  • Review of current literature on severe childhood asthma.
  • Analysis of physiologic and clinical presentations.
  • Evaluation of biomarker utility in predicting treatment response.

Main Results:

  • Severe asthma onset in children is often early.
  • Viral infection severity and atopic status are key predictors of onset.
  • Biomarkers show potential for predicting treatment response, yet significant patient variability exists.

Conclusions:

  • Effective management of severe childhood asthma requires a multifaceted approach.
  • Further research into personalized treatment strategies based on biomarkers and individual patient factors is warranted.