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Related Concept Videos

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Induced Pluripotent Stem Cells01:06

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation
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Stem Cell Banking: A Global View.

Glyn Stacey1

  • 1UK Stem Cell Bank, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, UK. glyn.stacey@nibsc.org.

Methods in Molecular Biology (Clifton, N.J.)
|March 30, 2017
PubMed
Summary
This summary is machine-generated.

Stem cell banking, including human embryonic stem cells (hESCs) and human induced pluripotency cells (hiPSCs), is evolving. This overview discusses the history, value, and future role of stem cell banks.

Keywords:
ChallengesHistoryHuman embryonic stem cellsInduced pluripotent stem cellsPluripotent stem cell banksRationale

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Area of Science:

  • Biotechnology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Stem cell banking has been debated for over a decade, following the establishment of public human embryonic stem cell (hESC) services.
  • Recent advancements and ambitious programs have revived interest in large-scale human induced pluripotency cell (hiPSC) line collections.

Purpose of the Study:

  • To provide a historical overview of stem cell bank development.
  • To assess the current value and future implications of stem cell banking.
  • To discuss the integration of hiPSC lines into existing banking frameworks.

Main Methods:

  • Literature review of stem cell banking initiatives.
  • Analysis of historical data on stem cell service establishment.
  • Discussion of current trends in hiPSC research and banking.

Main Results:

  • The field has progressed from early hESC banks to large-scale hiPSC initiatives.
  • Stem cell banks are crucial for research and therapeutic development.
  • The future likely involves integrated banking of diverse pluripotent cell types.

Conclusions:

  • Stem cell banking has a significant and evolving role in advancing biomedical research.
  • The development of hiPSC technology presents new opportunities and challenges for stem cell banks.
  • Continued discussion and strategic planning are essential for the future of stem cell banking.