Related Experiment Video
Updated: Mar 5, 2026
06:49
Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
Published on: March 14, 2014
12.1K
Inhibition of development ofPlanorbis exustus by chloramphenicol
Gajanan V Sherbet1, M S Lakshmi1,2
1Department of Zoology, University of Poona, Poona 7, India.
Wilhelm Roux' Archiv Fur Entwicklungsmechanik Der Organismen
|March 30, 2017
Summary
Chloramphenicol (CP) inhibits Planorbis exustus development, blocking cleavage at high doses and gastrulation at low doses. Reversibility depends on treatment duration, with early intervention allowing resumed development.
Area of Science:
- Developmental Biology
- Pharmacology
- Ecotoxicology
Background:
- Planorbis exustus serves as a model organism for studying aquatic snail development.
- Chloramphenicol (CP) is a broad-spectrum antibiotic with known effects on cellular processes.
Purpose of the Study:
- To investigate the impact of chloramphenicol (CP) on the embryonic development of Planorbis exustus.
- To determine concentration-dependent effects and reversibility of CP exposure.
Main Methods:
- Exposure of Planorbis exustus embryos to varying concentrations of chloramphenicol.
- Observation and documentation of developmental stages.
- Assessment of developmental recovery upon transfer to normal medium.
Main Results:
- High CP concentrations inhibited cleavage, while low concentrations blocked early gastrulation.
- Developmental inhibition was irreversible after 48 hours of CP exposure but reversible after 24 hours.
- Gastrulae developed normally in CP; a delay was noted between trochophore and hippo stages at low concentrations.
Conclusions:
- Chloramphenicol significantly disrupts Planorbis exustus embryonic development in a dose-dependent manner.
- The timing of CP exposure is critical for determining developmental inhibition and potential for recovery.
- Findings highlight the antilytic properties of CP and its implications for developmental processes.
Related Concept Videos
01:26Bacterial Phylum Planctomycetes
505
Planctomycetes are a group of morphologically distinct bacteria predominantly classified into two orders: Planctomycetales and Brocadiales. These gram-negative bacteria exhibit unique features, including division by budding and the presence of stalks or appendages. Their cells are often found in rosette arrangements, and they are notable for possessing an S-layer in their cell envelope, which is relatively uncommon among bacteria. Additionally, Planctomycetes frequently exhibit intracellular...
505
00:57Antibiotic Selection
61.6K
Overview
61.6K
01:30Development of Antibiotic Resistance
1.7K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.7K
01:28Gene Regulation in Microbial Communities: Quorum Sensing
790
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
790