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Updated: Mar 5, 2026
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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
Published on: December 7, 2012
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The platelets' perspective to pathogen reduction technologies.
Abdimajid Osman1,2, Walter E Hitzler3, Patrick Provost4,5
1a Department of Clinical Chemistry , Region Östergötland , Linköping , Sweden.
Platelets
|March 30, 2017
Summary
Pathogen reduction technologies (PRT) safeguard platelet transfusions but may harm platelet function. Further research is needed to balance pathogen inactivation with preserving platelet quality for transfusion safety.
Area of Science:
- Hematology
- Transfusion Medicine
- Biotechnology
Background:
- Platelet transfusions are crucial for managing low platelet counts and ensuring hemostasis.
- Pathogen reduction technologies (PRT) are increasingly used to mitigate transfusion-transmitted infections.
- Platelets possess a complex transcriptome with >5000 protein-coding RNAs and non-coding RNAs, influencing their function.
Purpose of the Study:
- To investigate the potential adverse effects of PRT on platelet function and microparticle release.
- To highlight the need for improved PRT or alternative methods that preserve platelet quality.
Main Methods:
- Review of current evidence on PRT and platelet function.
- Analysis of platelet transcriptome and its role in platelet biology.
- Consideration of platelet activation markers and microparticle formation.
Main Results:
- PRT may negatively impact platelet responsiveness and induce activation.
- Platelet activation can lead to the release of pro-inflammatory microparticles (MPs).
- PRT might enhance MP production in platelet concentrates (PCs).
Conclusions:
- The impact of PRT on platelet function requires further investigation.
- Developing PRT modifications or alternative pathogen inactivation methods is essential.
- Preserving platelet function is critical for improving the safety and efficacy of platelet transfusions.
Keywords:
Nucleic acidsRNA transcriptomepathogen reduction technologiesplatelet activationplatelet concentrateMore Related Videos
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