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Methods for analyzing observational longitudinal prognosis studies for rheumatic diseases: a review & worked example
Lily Siok Hoon Lim1,2,3, Eleanor Pullenayegum4, Rahim Moineddin5
1Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Canada. llim@chrim.ca.
Abstract:
Most outcome studies of rheumatic diseases report outcomes ascertained on a single occasion. While single assessments are sufficient for terminal or irreversible outcomes, they may not be sufficiently informative if outcomes change or fluctuate over time. Consequently, longitudinal studies that measure non-terminal outcomes repeatedly afford a better understanding of disease evolution.Longitudinal studies require special analytic methods. Newer longitudinal analytic methods have evolved tremendously to deal with common challenges in longitudinal observational studies. In recent years, an increasing number of studies have used longitudinal design. This review aims to help readers understand and apply the findings from longitudinal studies. Using a cohort of children with juvenile dermatomyositis (JDM), we illustrate how to study evolution of disease activity in JDM using longitudinal methods.