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The c-myc protein is associated with the nuclear matrix through specific metal interaction
J P Van Straaten1, T H Rabbitts
1Medical Research Council Laboratory of Molecular Biology, Cambridge, England.
Oncogene Research
|August 1, 1987
Abstract:
We have investigated the subnuclear localisation of the protein product of the c-myc oncogene. We show that, although c-myc is not present in the nuclear skeleton or matrix II fraction, it is associated with the nuclear matrix I fraction which is a complex group of proteins implicated in physiological processes within the nucleus. The interaction of the c-myc protein and the matrix I fraction is through a specific metal interaction and presumably, therefore, represents the in vivo location of this protein.