Related Experiment Videos
A Bioengineering Approach to Myopia Control Tested in a Guinea Pig Model
Mariana B Garcia1, Amit K Jha2, Kevin E Healy2
1Vision Science Graduate Group, University of California-Berkeley, Berkeley, California, United States.
Investigative Ophthalmology & Visual Science
|March 31, 2017
Summary
An injectable hydrogel and a buffer injection both reduced myopia progression in guinea pigs. The hydrogel demonstrated biocompatibility, supporting cell infiltration for potential drug delivery applications.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Regenerative Medicine
Background:
- Myopia progression is a significant global health concern.
- Current myopia control strategies have limitations.
- Injectable biomaterials offer potential for novel therapeutic approaches.
Purpose of the Study:
- To evaluate the biocompatibility of an injectable hydrogel.
- To assess the efficacy of the hydrogel in controlling myopia progression in a guinea pig model.
Main Methods:
- A hydrogel composed of acrylated hyaluronic acid was synthesized.
- Form deprivation was induced in 7-day-old guinea pigs.
- Sub-Tenon's capsule injections of hydrogel or buffer were administered.
- Ocular axial length and refractive error were measured.
Main Results:
- Both hydrogel and sham surgery significantly reduced axial elongation and myopia progression compared to controls.
- No significant adverse effects on intraocular pressure, visual acuity, or electroretinograms were observed.
- Histology confirmed extensive cell migration into the hydrogel implant.
Conclusions:
- Sub-Tenon's capsule injections of hydrogel and buffer effectively inhibit myopia progression.
- The hydrogel is biocompatible and supports cell infiltration, indicating potential for drug and cell delivery.
- The unexpected efficacy of buffer injections warrants further investigation for myopia control.