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Monocyte/lymphocyte ratio predicts the severity of coronary artery disease: a syntax score assessment

Hanhua Ji1, Yang Li2, Zeyuan Fan2

  • 1Department of Cardiology, Civil Aviation General Hospital, Civil Aviation Clinical Medical College of Peking University, No.1, Gaojingjia, Chaoyang District, Beijing, 100100, China. hanhuaji@foxmail.com.

BMC Cardiovascular Disorders
|April 1, 2017
PubMed

Insights

The monocyte to lymphocyte ratio (MLR) predicts coronary artery disease (CAD) presence and lesion severity. MLR demonstrates superior performance over neutrophil to lymphocyte ratio (NLR) in assessing coronary lesion severity.

Area of Science:

  • Cardiology
  • Hematology
  • Biomarkers

Background:

  • Coronary artery disease (CAD) poses a significant global health challenge.
  • Identifying reliable biomarkers for CAD severity is crucial for patient management.
  • The monocyte to lymphocyte ratio (MLR) is an emerging hematological parameter.

Purpose of the Study:

  • To investigate the predictive value of MLR for lesion severity in CAD patients.
  • To determine if MLR is an independent risk factor for CAD.
  • To compare the efficacy of MLR with neutrophil to lymphocyte ratio (NLR) in reflecting coronary lesion severity.

Main Methods:

  • Retrospective analysis of 543 patients undergoing coronary angiography.
  • Calculation of MLR from routine blood examination (monocytes/lymphocytes).
  • Multivariate logistic and ordinal logistic regression analyses to assess risk factors and lesion severity correlation.
  • Receiver-operating characteristic (ROC) curve analysis for optimal cut-off determination.

Main Results:

  • MLR is an independent risk factor for CAD presence (OR: 3.94) and a predictor of lesion severity (OR: 2.05).
  • MLR showed a positive correlation with Syntax score (r=0.437, p<0.001).
  • Optimal MLR cut-off of 0.25 predicted severe coronary lesions with 60.26% sensitivity and 78.49% specificity.

Conclusions:

  • MLR is a valuable independent risk factor for CAD and a predictor of its lesion severity.
  • MLR exhibits superior performance compared to NLR in reflecting the severity of coronary lesions.
  • MLR can serve as a useful, readily available biomarker in the clinical assessment of CAD.
Abstract

Keywords:
Coronary artery diseaseMonocyte to lymphocyte ratioSyntax score

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