Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathophysiology of Migraine.

H Evren Boran1, Hayrunnisa Bolay1

  • 1Gazi University, Medical Faculty, Department of neurology, Ankara, Turkey.

Noro Psikiyatri Arsivi
|April 1, 2017
PubMed
Summary

Migraine pathophysiology involves neuronal mechanisms and brain region activation, with recent studies using advanced imaging techniques like PET and fMRI highlighting connections to vasodilatation and neurogenic inflammation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing the relationships between migraine and driving risks, challenges and coping strategies.

Scientific reports·2026
Same author

tVNS Mitigates Neuroinflammation and Nociception in a Rodent LPS Endotoxemia Model.

Clinical and translational science·2026
Same author

Kinematic analysis of multisensory integration and sensory load induced fatigue in migraine.

Scientific reports·2026
Same author

The Effects of Migraine on Driving Safety, Habits, and Risk Perception.

Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES·2026
Same author

Follow-Up of Post-Traumatic Headache Patients: A Multicenter Prospective Study on Headache Phenotype and Impact after Mild Traumatic Brain Injury.

Journal of neurotrauma·2026
Same author

BOLD repetition enhancement in the orbitofrontal cortex during complex visuospatial processing in migraine without aura: a shift in periaqueductal gray - cortical coupling?

The journal of headache and pain·2026

Area of Science:

  • Neuroscience
  • Neurology

Background:

  • Migraine is a prevalent neurological disorder impacting over 10% of the population, significantly reducing quality of life.
  • The precise pathophysiology of migraine, including the origin of pain and activated brain regions during different phases, remains incompletely understood.
  • Current research increasingly points towards primary neuronal mechanisms underlying migraine.

Purpose of the Study:

  • To elucidate the underlying neuronal mechanisms and brain region involvement in migraine pathophysiology.
  • To explore the role of advanced neuroimaging techniques in understanding migraine and cluster headaches.
  • To investigate the relationship between cortical excitability and migraine phases.

Main Methods:

  • Utilizing advanced neuroimaging techniques such as positron emission tomography (PET) and functional magnetic resonance imaging (fMRI).
  • Examining experimental models, including rodent studies focusing on trigeminal nerve activation and cortical spreading depression.
  • Analyzing data from the past decade to assess cortical excitability during interictal phases.

Main Results:

  • Neuroimaging studies suggest a link between migraine, cluster headaches, neuronal structures, and vasodilatation.
  • Evidence indicates increased cortical excitability during the interictal phase of migraine.
  • Rodent studies demonstrate trigeminal nerve activation leading to vasodilatation and neurogenic inflammation during the headache phase.

Conclusions:

  • Migraine pathophysiology is associated with primary neuronal mechanisms and involves specific brain regions.
  • Advanced imaging techniques are crucial for understanding the neurovascular aspects of migraine and cluster headaches.
  • Further research, particularly on the aura model and cortical spreading depression, is needed to fully unravel migraine pathophysiology.
Keywords:
Migraineauracortical excitabilitycortical spreading depressiontrigeminovascular system

Related Experiment Videos