Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Longitudinal changes in adolescents with TOF: implications for care.

Misha Bhat1, Laura Mercer-Rosa2, Mark A Fogel2

  • 1Department of Pediatric Cardiology, Pediatric Heart Center, Avd 67 Skåne University Hospital in Lund, SE-221-85 Lund, Sweden.

European Heart Journal. Cardiovascular Imaging
|April 1, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Minimum data requirements and automated preprocessing for reliable EEG biomarkers in Rett syndrome.

Frontiers in neurology·2026
Same author

Normative modeling for quantitative brain MRI phenotyping and biomarker discovery for pediatric leukodystrophies.

medRxiv : the preprint server for health sciences·2026
Same author

Developmental trajectory of individuals with Pelizaeus-Merzbacher Disease (PMD).

Molecular genetics and metabolism·2026
Same author

Deletion size and background genetic variation shape congenital heart disease phenotypes in 3,016 individuals with 22q11.2 deletion syndrome.

medRxiv : the preprint server for health sciences·2026
Same author

Quality of Bag-Mask Ventilation for Children Before Intubation: Single-Center PICU Pilot Observational Study, 2019-2022.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2026
Same author

Characterizing Engagement With a Mobile Health Application Designed for Adolescents and Young Adults With Sickle Cell Disease: Findings From the COMETS Study.

Pediatric blood & cancer·2026

In adolescents after tetralogy of Fallot repair, longer time since surgery, increased pulmonary insufficiency, and initial right ventricular dilation predict worsening right ventricular dilation. Early MRI monitoring can identify high-risk patients for progressive disease.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Congenital Heart Disease

Background:

  • Tetralogy of Fallot (TOF) repair in adolescents requires ongoing monitoring for right ventricular (RV) health.
  • Predicting changes in RV function and exercise capacity post-repair is crucial for long-term outcomes.

Purpose of the Study:

  • To identify predictors of changes in right ventricular function and exercise capacity in adolescents following surgical repair of tetralogy of Fallot.

Main Methods:

  • Longitudinal study utilizing serial cardiac magnetic resonance imaging (CMR) and exercise stress tests.
  • Exclusion of patients with interim pulmonary valve interventions.
  • Multivariable regression models used to identify predictors of longitudinal changes in RV parameters.
Keywords:
outcomepulmonary insufficiencyright ventricletetralogy of Fallot

Related Experiment Videos

Main Results:

  • Significant increases in RV end-diastolic and end-systolic volumes, alongside a decrease in RV ejection fraction over follow-up.
  • Time elapsed since surgical repair, severity of pulmonary insufficiency, and initial RV dilation were significant predictors of RV dilation.
  • No significant changes were observed in pulmonary regurgitant fraction, RV cardiac index, or exercise capacity.

Conclusions:

  • Progressive right ventricular dilation in adolescents with repaired TOF is associated with longer time from surgery, greater pulmonary insufficiency, and baseline RV dilation.
  • Early and regular CMR monitoring is recommended to identify individuals at higher risk for progressive RV dilation and adverse outcomes.