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Oxidative DNA damage & repair: An introduction.

Jean Cadet1, Kelvin J A Davies2

  • 1Département de Médecine Nucléaire et Radiobiologie, Faculté de Médecine de des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada J1H 5N4.

Free Radical Biology & Medicine
|April 2, 2017
PubMed
Summary

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DNA oxidation is a major consequence of life in an oxygen-rich environment. DNA repair enzymes evolved to counteract this damage, enabling survival.

Area of Science:

  • Free Radical Biology & Medicine
  • Biochemistry
  • Molecular Biology

Background:

  • DNA oxidation is an unavoidable consequence of aerobic life.
  • Oxygen-rich environments pose a constant threat of DNA damage.
  • Professor Tomas Lindahl's work on DNA repair is foundational.
Keywords:
DNA damageDNA oxidationDNA repairNobel PrizeOxidative stressThomas Lindahl

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