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PhagesDB: the actinobacteriophage database.

Daniel A Russell, Graham F Hatfull

    Bioinformatics (Oxford, England)
    |April 3, 2017
    PubMed
    Summary
    This summary is machine-generated.

    The Actinobacteriophage Database (PhagesDB) organizes global research on bacteriophages, viruses infecting Actinobacteria. It hosts over 8000 phages, including 1600 with sequenced genomes, aiding scientific discovery.

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    Area of Science:

    • Microbiology
    • Bioinformatics
    • Genomics

    Background:

    • Actinobacteria are a diverse group of bacteria with significant environmental and clinical relevance.
    • Bacteriophages (phages) are viruses that infect bacteria and play critical roles in microbial ecosystems.
    • Understanding phage diversity and genomics is essential for various applications, including phage therapy.

    Purpose of the Study:

    • To establish and maintain a comprehensive, interactive database for Actinobacteriophage research.
    • To facilitate the collection, organization, and sharing of data on bacteriophages infecting Actinobacteria.
    • To support the global community of phage biologists, including students and researchers.

    Main Methods:

    • Development and maintenance of a database-backed website (PhagesDB).

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  • Systematic collection of data on bacteriophage discovery and characterization.
  • Integration of genomic data for sequenced bacteriophages.
  • Facilitation of data sharing and accessibility for researchers worldwide.

    • Main Results:

    • PhagesDB currently contains over 8000 bacteriophages.
    • More than 1600 bacteriophages in the database have sequenced genomes.
    • The database has been cited in over 50 peer-reviewed articles, demonstrating its utility.
    • PhagesDB serves as a central resource for the international phage research community, including the SEA-PHAGES program.

    Conclusions:

    • PhagesDB is a vital resource for consolidating and disseminating knowledge on Actinobacteriophages.
    • The database significantly contributes to the advancement of phage biology and genomics research.
    • PhagesDB plays a key role in organizing and promoting global phage research efforts.