Longitudinal Assessment of Dentate Nuclei Relaxometry during Massive Gadobutrol Exposure

We report the assessment of Dentate Nuclei (DN) R1 (1/T₁) and R2* (1/T₂*) values in a patient with relapsing-remitting Multiple Sclerosis, exposed to 22 standard (0.1 mmol/kg) doses of gadobutrol, who underwent eight relaxometric MR measurements within 2 years. DN R1 did not significantly increase nor correlated with cumulative gadobutrol administration, even after a total dose of 130 ml. Likewise, DN R2* relaxometry remained unchanged. In conclusion, massive gadobutrol exposure did not induce significant DN relaxometry changes.