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System pharmacogenomics application in infectious diseases.

Vineetha Mandlik, Ritika Kabra, Shailza Singh

    Briefings in Functional Genomics
    |April 4, 2017
    PubMed
    Summary

    Systems pharmacology advances human biology and personalized medicine through mathematical models and high-throughput technologies. This review explores infectious disease pharmacogenomics and discusses readiness for widespread adoption.

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    Area of Science:

    • Systems pharmacology and its impact on human biology.
    • Integration of mathematical models and systems biology.
    • Advancements in high-throughput technologies.

    Background:

    • The paradigm shift in medical/clinical practice towards precise treatment and safety.
    • Growing recognition of mathematical models for disease pathology and epidemiology.
    • Emergence of systems pharmacogenomics driven by systems biology.

    Purpose of the Study:

    • To detail infectious disease pharmacogenomics.
    • To explore developments in systems pharmacology and personalized medicine.
    • To address regulatory considerations for universal adoption.

    Main Methods:

    • Review of systems pharmacology principles.
    • Analysis of high-throughput technologies in biology.
    Keywords:
    biological networksinfectious diseasesystem pharamcogenomics

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  • Examination of mathematical modeling in disease understanding.

    • Main Results:

    • Systems pharmacology offers precise treatment, adequate response, and safety.
    • High-throughput technologies and systems biology enable systems pharmacogenomics.
    • Personalized medicine is a key focus area.

    Conclusions:

    • Systems pharmacology has revolutionized human biology and clinical practice.
    • Further development in infectious disease pharmacogenomics is highlighted.
    • Regulatory readiness for universal adoption requires consideration.