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Genetic susceptibility to severe asthma with fungal sensitization

N L Overton1,2, A Simpson1, P Bowyer1,2

  • 1Division of Infection Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, The University of Manchester, Manchester, UK.

International Journal of Immunogenetics
|April 4, 2017
PubMed

Insights

Genetic factors influence severe asthma with fungal sensitization (SAFS). This study identified specific gene variants associated with SAFS, offering insights into its distinct pathogenesis compared to other asthma types.

Area of Science:

  • Immunogenetics
  • Pulmonary Medicine
  • Molecular Biology

Background:

  • Severe asthma is a significant clinical challenge with poorly understood mechanisms.
  • Fungal sensitization is prevalent in severe asthma, and some patients (SAFS) respond to antifungal treatments.

Purpose of the Study:

  • To investigate genetic associations in severe asthma with fungal sensitization (SAFS).
  • To compare genetic findings in SAFS with atopic asthma and healthy controls.

Main Methods:

  • Genotyped 325 haplotype-tagging SNPs in 22 candidate genes.
  • Compared 47 SAFS patients with 152 atopic asthmatics and 279 healthy controls.

Main Results:

  • Identified significant associations in SAFS patients for Toll-like receptor 3 (TLR3), TLR9, dectin-1, interleukin-10 (IL-10), mannose-binding lectin (MBL2), CCL2, CCL17, plasminogen, and adenosine A2a receptor.
  • These genetic associations differed from those observed in allergic bronchopulmonary aspergillosis (ABPA) in asthma.

Conclusions:

  • Genetic findings suggest distinct pathogenic pathways for SAFS compared to other asthma phenotypes.
  • Further genetic and experimental studies are needed to elucidate the diverse mechanisms underlying severe asthma.
Keywords:
allergyasthmadisease associationdisease association studiesgeneticspolymorphism

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