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Related Experiment Videos

DRD2: Bridging the Genome and Ingestive Behavior.

Xue Sun1, Serge Luquet2, Dana M Small3

  • 1Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA.

Trends in Cognitive Sciences
|April 5, 2017
PubMed
Summary
This summary is machine-generated.

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Genetic variants in FTO and TaqIA influence dopamine signaling, impacting obesity risk and cognitive function. These gene-environment interactions highlight pathways for overeating and cognitive decline.

Area of Science:

  • Neuroscience
  • Genetics
  • Obesity Research

Background:

  • Genetic variants impact brain structure and function, influencing polygenic obesity risk.
  • Dopamine (DA) signaling is crucial for energy balance, integrating metabolic signals with feeding-related cognitive and appetitive functions.
  • Diet and obesity disrupt DA signaling, potentially leading to compulsive eating and cognitive deficits.

Purpose of the Study:

  • To investigate the role of common gene variants (FTO and TaqIA rs1800497) in gene × environment interactions.
  • To examine how these variants influence dopamine receptor subtype 2 (DRD2) signaling.
  • To understand their contribution to obesity, metabolic dysfunction, and cognitive changes.

Main Methods:

  • Analysis of gene variants FTO and TaqIA rs1800497.
Keywords:
ANKK1cognitiondietdopaminegeneticsinflammationingestive behaviorobesity

Related Experiment Videos

  • Assessment of their influence on dopamine receptor subtype 2 (DRD2) signaling pathways.
  • Evaluation of gene × environment interactions in relation to obesity and cognitive function.

    • Main Results:

    • FTO and TaqIA rs1800497 variants play a role in gene × environment interactions.
    • These interactions promote obesity, metabolic dysfunction, and cognitive alterations.
    • Influence on dopamine receptor subtype 2 (DRD2) signaling is a key mechanism.

    Conclusions:

    • Common genetic variants can confer risk for obesity and cognitive decline through altered dopamine signaling.
    • Gene × environment interactions involving FTO and TaqIA are implicated in obesity and associated cognitive changes.
    • Targeting DRD2 signaling pathways may offer therapeutic strategies for obesity and cognitive impairments.