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Updated: Sep 19, 2026

Deep Brain Stimulation with Simultaneous fMRI in Rodents
Published on: February 15, 2014
High-voltage VIM Region Deep Brain Stimulation Mimicking Progressive Supranuclear Palsy
Addie Patterson1, Michael S Okun1, Christopher Hess1
1Department of Neurology, University of Florida, Gainesville, FL, USA.
Background:
Deep brain stimulation (DBS) for essential tremor (ET) can cause unwanted side effects.
Case Report:
A patient with ET underwent unilateral dual-lead thalamic DBS. He later developed parkinsonism with atypical features and was diagnosed with progressive supranuclear palsy. During presentation for a second opinion, stimulation-induced side effects were suspected. Inactivation of DBS resolved atypical features and superimposed idiopathic Parkinson disease (PD) was diagnosed.
Discussion:
This case illustrates the importance of recognizing the possible influence of stimulation-induced side effects and discusses when to utilize dual-lead DBS for ET and the co-occurrence of ET and PD.

