Related Experiment Video

Updated: Jun 24, 2026

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
10:34

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

Hydrocephalus after Subarachnoid Hemorrhage: Pathophysiology, Diagnosis, and Treatment

Sheng Chen1, Jinqi Luo1, Cesar Reis2

  • 1Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Brain Research Institute, Zhejiang University, Hangzhou, China.

Biomed Research International
|April 5, 2017
PubMed

Insights

Hydrocephalus after subarachnoid hemorrhage involves inflammation and oxidative stress. Current treatments focus on surgery, while new therapies are in early development.

Area of Science:

  • Neuroscience and Neurology
  • Neurosurgery
  • Molecular Biology

Background:

  • Hydrocephalus (HCP) is a frequent complication following subarachnoid hemorrhage (SAH).
  • Understanding the molecular mechanisms and therapeutic advancements for post-SAH HCP is crucial.

Purpose of the Study:

  • To review current research on hydrocephalus following subarachnoid hemorrhage.
  • To explore the molecular origins, diagnostic methods, and treatment strategies for HCP post-SAH.

Main Methods:

  • Comprehensive literature review of advanced research on hydrocephalus after subarachnoid hemorrhage.
  • Analysis of molecular pathways, diagnostic approaches, and surgical interventions.

Main Results:

  • Key molecular contributors to HCP include inflammation, apoptosis, autophagy, and oxidative stress.
  • Transforming growth factor, matrix metalloproteinases, and iron are implicated in fibrosis and blockage.
  • Surgery remains the primary treatment, with various methods like lamina terminalis fenestration and shunting procedures.

Conclusions:

  • Hydrocephalus post-SAH is a significant condition requiring further research into its development and improved patient prognosis.
  • While surgical interventions are effective, they carry inherent risks, and pharmacological treatments are still in preclinical stages.

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