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Related Experiment Videos

Longitudinal Changes in Component Processes of Working Memory.

Anna Rieckmann1, Sara Pudas2, Lars Nyberg1

  • 1Department of Radiation Sciences, Umeå University, 901 87 Umeå, Sweden; Center for Functional Brain Imaging, Umeå University, 901 87 Umeå, Sweden; Department of Integrative Medical Biology, Umeå University, 901 87 Umeå, Sweden.

Eneuro
|April 5, 2017
PubMed
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Aging affects working memory (WM) differently in the brain. Parietal regions support maintenance, while frontal regions aid manipulation, with only frontal changes linked to performance decline in older adults.

Area of Science:

  • Neuroscience
  • Cognitive Aging
  • Neuroimaging

Background:

  • Working memory (WM) involves maintaining and manipulating information without sensory input.
  • Aging is associated with changes in cognitive functions, including WM.
  • Understanding the neural basis of age-related WM decline is crucial.

Purpose of the Study:

  • To investigate the longitudinal changes in the neural basis of working memory maintenance and manipulation in aging.
  • To examine the dissociable roles of parietal and frontal brain regions in these WM components over time.
  • To explore the relationship between brain activity changes, performance, and study dropout in older adults.

Main Methods:

  • Longitudinal functional magnetic resonance imaging (fMRI) in 136 older adults (55-80 years) over 4 years.
Keywords:
Working memoryagingfMRIfronto-parietallongitudinal

Related Experiment Videos

  • Analysis of age-related changes in parietal and frontal components of the WM core network.
  • Individual difference analyses comparing performance subgroups.

    • Main Results:

    • Age-related changes in parietal and frontal WM networks are dissociable.
    • Parietal regions are linked to maintenance, while frontal regions are associated with manipulation.
    • Only prefrontal activation changes correlated with performance changes; parietal activity related to dropout.

    Conclusions:

    • Aging differentially affects WM maintenance (parietal cortex) and manipulation (prefrontal cortex).
    • Prefrontal cortex changes are more directly linked to observable performance declines in WM.
    • Neurobiological declines in inferior parietal and lateral prefrontal cortices underlie separable WM aging effects.