Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change

Didac Vidal-Piñeiro1, Øystein Sørensen2, Marie Strømstad2

  • 1Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway. d.v.pineiro@psykologi.uio.no.

Nature Communications
|November 21, 2025
PubMed
Summary

Brain atrophy accelerates memory loss in aging, especially with significant brain structure decline. This association strengthens with age but isn't influenced by Alzheimer's genetic risk.