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Two new biflavonones from Coreopsis tinctoria
Ren-Jie Yan1, Mo-Ying Li1, Hai-Feng Zhou1
1a State Key Laboratory of New Drug & Pharmaceutical Process , Shanghai Institute of Pharmaceutical Industry , Shanghai 200040 , China.
Journal of Asian Natural Products Research
|April 5, 2017
Summary
Two novel biflavonone compounds, sikokianin D and E, were identified in Coreopsis tinctoria. Their chemical structures were determined using advanced spectroscopic methods.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Organic Chemistry
Background:
- Coreopsis tinctoria is a plant species known for its potential medicinal properties.
- Biflavonones are a class of natural compounds with diverse biological activities.
Purpose of the Study:
- To isolate and characterize new chemical constituents from Coreopsis tinctoria.
- To elucidate the structures of novel biflavonone compounds.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation employing Nuclear Magnetic Resonance (NMR) spectroscopy.
- High-Resolution Electrospray Ionization Mass Spectrometry (HRESIMS) for molecular formula determination.
- Circular Dichroism (CD) spectroscopy for stereochemical analysis.
Main Results:
- Two new biflavonone compounds, designated sikokianin D (1) and sikokianin E (2), were successfully isolated.
- The complete structures of compounds 1 and 2 were determined through comprehensive spectroscopic analysis.
Conclusions:
- The study expands the knowledge of chemical diversity within the Coreopsis genus.
- The identified compounds, sikokianin D and E, represent new additions to the known biflavonone family.
- Further research may explore the biological activities of these novel compounds.